Pediatric dosing: patients <2 years of age1
As in adults1:
- Initiate sotalol treatment in hospital after appropriate clinical assessment
- Regimen should be individualized, as appropriate
- Dosage should be increased gradually, if required
- Carefully assess therapeutic response and tolerability
- Conduct frequent monitoring of QTc interval and heart rate
Sotalol IV dose should be reduced by a factor that depends on age*
Intravenous sotalol has not been studied in children. Potency is thought to be similar in children, so a dose of 30 mg/m2 every 8 hours should give exposure similar to that with 160 mg daily in adults. Table below shows suggested starting doses in children with normal renal function. With impaired renal function, start lower and titrate less frequently.
Suggesting starting doses [mg/kg] in children with normal renal function1
For children aged about 2 years and greater with normal renal function, doses normalized for body surface area are appropriate for both initial and incremental dosing.