Select the target oral dosing therapy*:
- Initiate therapy at 80mg or 120mg
- For dose escalation: 80mg to 120mg
- For dose escalation: 120mg to 160mg
All initiations and dose escalations utilize a Sotalol IV infusion of 1 hour.
* Patient discharge is dependent on overall clinical evaluation, renal function and response to therapy. Creatinine Clearance >60mL/min may permit discharge within 20-24 hours. Timing of patient discharge may vary from the example provided.
Recommended loading dosage1
The intravenous loading dose depends on the target oral dose and creatinine clearance; the dosing interval for oral administration of sotalol and the minimum delay between the end of the infusion and the first oral dose also depend on renal function.1
- Monitor QTc interval every 15 minutes during infusion
- Continue to monitor QTc around Tmax after 1st and 2nd oral doses (2 to 4 hours post-dose)
Do you treat pediatric patients? See Sotalol IV dosing adjustments by age.
Contraindicated in patients with:1
- Sinus bradycardia (<50 bpm), sick sinus syndrome or second or third degree AV block without a pacemaker
- Congenital or acquired long QT syndromes, QT interval >450 ms
- Cardiogenic shock, decompensated heart failure
- Serum potassium <4 mEq/L
- Bronchial asthma or related bronchospastic conditions
- Known hypersensitivity to sotalol