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Considerations When Implementing Sotalol IV In Your Practice

Brad Knight, MD discusses some considerations when integrating Sotalol IV into your hospital workflow

Description

Learn from Dr. Bradley Knight, Director of Cardiac Electrophysiology at Northwestern Medicine, on key safety and efficiency considerations when implementing a Sotalol IV protocol at an institution. Also, why he believes atrial fibrillation is “an epidemic.”

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References

  1. Sotalol IV [package insert]. Chicago, IL: AltaThera Pharmaceuticals; 07/2025. sotaloliv.com/pi

Dr. Knight’s appearance in this video was sponsored by AltaThera. 

SIV-VID-004.1-072025

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Highlights of Prescribing Information

Boxed Warning, Indications, and Important Safety Information

WARNING: LIFE THREATENING PROARRHYTHMIA

Sotalol can cause life threatening ventricular tachycardia associated with QT interval prolongation. To minimize the risk of drug induced arrhythmia, initiate or uptitrate intravenous sotalol in a facility that can provide continuous electrocardiographic monitoring and cardiac resuscitation [see Dosage and Administration (2.3) and Warnings and Precautions (5.1)].
Do not initiate intravenous sotalol therapy if the baseline QTc is longer than 450 ms. If the QTc prolongs to 500 ms or greater, reduce the dose or discontinue.