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Case Study: Achieving success when implementing Sotalol IV

Video interview with Benjamin Steinberg, MD, MHS, FACP, FACC, FHRS

Description

At HRS 2024, we sat down with Dr. Benjamin Steinberg to discuss what success looks like in implementing a Sotalol IV protocol at an institution. In addition to highlighting some important things to watch out for during loading, Dr. Steinberg reviews some of the potential resource savings that come along with implementing the protocol.

About Dr. Benjamin Steinberg: 

Benjamin A. Steinberg, MD, MHS, FACP, FACC, FHRS is a clinical cardiac electrophysiologist currently serving as Electrophysiology Director at Denver Health and Associate Professor at the University of Colorado Anschutz Medical Campus. He received his medical degree from The Johns Hopkins University School of Medicine and completed internal medicine residency on the Osler Medical Service at The Johns Hopkins Hospital and fellowships in cardiovascular disease, clinical research, and clinical cardiac electrophysiology at Duke University. His current research is geared towards personalizing treatments for patients with atrial fibrillation (AF) and other heart rhythm disorders. Dr. Steinberg has authored or co-authored nearly 200 books, chapters, and peer-reviewed articles in leading journals. He is the lead PI and steering committee chair for the PEAKS multisite registry studying intravenous sotalol.

Dr. Steinberg’s appearance in this video was sponsored by AltaThera.

Note: At the time of this video’s recording, Dr. Steinberg was affiliated with University of Utah School of Medicine.

References

  1. Sotalol IV [package insert]. Chicago, IL: AltaThera Pharmaceuticals; 2023. sotaloliv.com/pi
  2. BetaPace [package insert]. Zug, Switzerland: Covis Pharma; 2023.
  3. Somberg JC, Vinks AA, Dong M, Molnar J. Model-Informed Development of Sotalol Loading and Dose Escalation
    Employing an Intravenous Infusion. Cardiol Res. 2020;11(5):294-304. doi:10.14740/cr1143
  4. Steinberg BA, Holubkov R, Deering T, et al. Expedited Loading with Intravenous Sotalol is Safe and Feasible – Primary Results of the Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry. Heart Rhythm. Published online February 26, 2024. doi:10.1016/j.hrthm.2024.02.046
 
SIV-POD-005.1-062024
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Highlights of Prescribing Information

Boxed Warning, Indications, and Important Safety Information

WARNING: LIFE THREATENING PROARRHYTHMIA

Sotalol can cause life threatening ventricular tachycardia associated with QT interval prolongation. To minimize the risk of drug induced arrhythmia, initiate or uptitrate intravenous sotalol in a facility that can provide continuous electrocardiographic monitoring and cardiac resuscitation [see Dosage and Administration (2.3) and Warnings and Precautions (5.1)].
Do not initiate intravenous sotalol therapy if the baseline QTc is longer than 450 ms. If the QTc prolongs to 500 ms or greater, reduce the dose or discontinue.