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Badani, H, Seo, B.W., Peyerl, F.W. PVC21 Pharmacoeconomic analysis of sotalol loading: Comparison of 1-day inpatient loading of IV Sotalol compared to the standard 3-day loading protocol. Value in Health, 22 2:122, May 2019. doi:10.1016/j.jval.2019.04.457

In a May 2019 article in Value in Health Journal, Seo et al perform a pharmacoeconomic analysis of sotalol loading comparing the costs and benefits of a 1-day inpatient loading of IV sotalol versus the standard 3-day loading protocol of oral sotalol by creating a budget impact model to estimate changes in hospital costs, savings, and revenue. The results suggest that the overall cost of initiating drug therapy per patient for the hospital can be reduced $2,900 by using IV sotalol compared to oral sotalol.

Highlights of Prescribing Information

Boxed Warning, Indications, and Important Safety Information


Sotalol can cause life threatening ventricular tachycardia associated with QT interval prolongation. To minimize the risk of drug induced arrhythmia, initiate or uptitrate intravenous sotalol in a facility that can provide continuous electrocardiographic monitoring and cardiac resuscitation [see Dosage and Administration (2.3) and Warnings and Precautions (5.1)].
Do not initiate intravenous sotalol therapy if the baseline QTc is longer than 450 ms. If the QTc prolongs to 500 ms or greater, reduce the dose or discontinue. (2.3)